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Data availability The protein structure from accession codes 1e17 (FOXO4 FHD) was obtained from the PDB at All other data are available from the corresponding author upon reasonable request

In vitro studies on human keratinocytes show a reduction in inflammatory cytokine production of over 50%

Because beta-oxidation can sometimes produce acetyl-CoA at a rate faster than the Krebs cycle can handle, intermediate molecules can accumulate, resulting in less efficient energy generation

Additionally, investments in R&D and collaborations between biotech firms and academic institutions are likely to pave the way for further advancements