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Severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) occurred in 6.5% and 10.4% of patients when semaglutide 0.5 mg and 1 mg, respectively, when coadministered with a sulfonylurea
The driver may be mast-cell-mediated or systemic rather than NF-B-local, and if so, increasing the dose for additional KPV will not address it see the mast-cell note under Phenotype Considerations
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