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It binds to guanine triphosphate (GTP), which results in the conformational changes that later trigger the signal transduction of different G-proteins: inhibitory G-protein (G i ), stimulatory G-protein (G s ), and guanine-nucleotide binding protein (G q ) (79)

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It is important to note that AE1plays an important role in the maintenance of the structural integrity of erythrocytes, providing interactions between the membrane and the cytoskeleton, supporting the cytoskeletal connectivity, and maintaining the biconcave shape of erythrocytes [92]