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This preserves the natural pulsatile release pattern and negative feedback mechanisms, typically resulting in a safer side effect profile (Prakash & Bhatt, 2013, Indian Journal of Endocrinology and Metabolism )
(200 g kg 1 , 50 nmol kg 1 )) formulated at 20 g mL 1 in PBS 1
It is recommended to follow the dosage instructions on the product label for optimal results
[11] Clinical studies such as the SUSTAIN programme (semaglutide) and AWARD trials (dulaglutide) demonstrate that GLP-1 receptor agonists can reduce HbA1c by approximately 0.81.5% on average, with some patients achieving greater reductions depending on baseline values and adherence
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