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Cystathionine beta-synthase deficiency causes fat loss in mice

Warnings: Thyroid Tumors: Due to an observed risk in rodent studies, there is a warning regarding potential C-cell tumors in the thyroid

Liraglutide, semaglutide and tirzepatide are incretin-based therapies currently approved by FDA for the management of obesity, while triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), the cagrilintide/semaglutide (CagriSema) 2.4 mg combination, high-dose oral semaglutide, and oral orforglipron are in advanced stages of development