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Notably, the so-far available evidence on GIP/GLP-1 RAs efficacy in T2DM is striking, with tirzepatide (15 mg once weekly) appearing superior both compared to placebo and GLP-1RAs for glycemic control and body weight reduction, and also superior to basal insulin for glycemic control, without increasing the risk for hypoglycemia
Each dose increase essentially restarts a short adjustment period for your digestive system, and giving your body four weeks between steps gives it time to catch up before the next increase
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