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The full scope at Ascend includes: Obesity and overweight with comorbidities - full workup, GLP-1 candidacy assessment, lifestyle integration Type 2 diabetes with weight management goals - GLP-1 medications often address both indications simultaneously Hypertension tied to weight - coordinated medication review and lifestyle work Dyslipidemia and metabolic syndrome - lipids often improve markedly with weight loss Prediabetes - HbA1c 5.7-6.4% range, where intervention can prevent progression Fatty liver disease (MASLD) - weight loss is the primary intervention

[11] [12] The SURPASS-2 trial showed that tirzepatide has broadly similar gastrointestinal adverse event rates to semaglutide 1 mg, with both medications showing dose-dependent effects

This heterogeneity means that different subsets of tumor cells may respond differently to treatment, complicating therapeutic efforts

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