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Careful Administration (Use with Caution) 12.1 Patients with Renal Impairment Renal impairment necessitates cautious use

Diabetic retinopathy complications: Patients with pre-existing diabetic eye disease should have regular ophthalmology reviews, as rapid improvement in blood glucose control can temporarily worsen retinopathy

Researchers should resist the temptation to escalate faster than the standard protocol, as doing so increases the likelihood and severity of GI events

Analyses of other subgroups were planned post hoc, including race (White or Non-White), country (US or non-US) and baseline SGLT-2i use (yes or no)