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Importantly, in some B-ALL and T-ALL cell lines and cells derived from patients with B-ALL, reduction of the glycolytic rate using 2-deoxy-D-glucose (2-DG), lonidamine (LND), or 3-bromopyruvate (3-BrPA), can restore the sensitivity of these cells to glucocorticoids (Hulleman et al., 2009

The GT-1 incorporates an optical design that doesn't require different 'modes' to activate and so all feature functionality is available at any time

The narrow pocket of mTYR and the long side chain of CME limit the available conformations for CME during the docking process

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