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Another mechanism involves the circadian rhythm theory, which emphasizes synchronizing eating patterns with circadian clocks to optimize glucose and fat metabolism [77]
Together, these two pathways produce a broader metabolic response than GLP-1 activation alone, which is why tirzepatide has shown more pronounced effects on body weight and blood sugar control in clinical research compared to GLP-1-only medications
However, exenatide is considered the most efficient in crossing the BBB based on its rate of brain influx, its percentage reaching the brain that accumulates in the brain parenchyma, and the percentage of the systemic dose taken up per gram of brain tissue [18]
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