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Chronic use of these medications without concurrent glutathione support may contribute to long-term oxidative stress accumulation and cellular dysfunction

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The cryo-EM maps allowed us to build an unambiguous model for most regions of the complexes except for the flexible -helical domain (AHD) of G and the stalk between transmembrane helice 1 (TM1) and extracellular domain (ECD), which were poorly resolved in most cryo-EM structures of GPCRG s complex (Supplementary Fig